发育性协调障碍儿童听觉事件相关电位测定

Study on auditory event-related potential of developmental coordination disorder

目的探讨发育性协调障碍(DCD)儿童听觉事件相关电位P300,从电生理水平分析DCD发病机制,为DCD的病因研究提供依据。方法以《美国精神障碍诊断与统计手册》第4版为诊断标准,结合发育性协调障碍问卷在2所小学中进行筛查,筛选出16名DCD儿童,按1:1配对选择对照;通过协方差分析比较不同组儿童P300的潜伏期与波幅。对受试儿童运动表现与P300潜伏期与波幅进行偏相关分析。结果DCD儿童与对照组儿童P300潜伏期差异无统计学意义(P>0.05),而P300波幅组间差异有统计学意义(P<0.01);受试儿童运动技能障碍程度与听觉P300的波幅呈负相关(r=-0.906,P<0.01)。结论智力和年龄是影响P300电位的重要因素,DCD儿童P300波幅异常表明其存在运动控制功能缺陷。

Objective To investigate the auditory event- related potential P300 of developmental coordination disorder （DCD）, and to analyze its mechanism from electophysiological level so as to provide guidance for etiological study. Methods 16 DCD children from two primary school were screened with the diagnostic standard of American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders（4th ed） and developmental coordination disorder questionnaire, and the control group children were selected according to the principle of 1 ： 1 matching. Covariate ANOVA were performed to study the latency and amplitude of P300 among different group, and partial correlate analysis to study the relationship between the subjects＇ movement performance and their latency and amplitude of P300. Results There were no difference in P300 latency between the DCD and control group（ P 〉 0.05）, but there were difference in P300 amplitude between them（ P 〈 0.01 ）. Furthermore there were highly correlation between children＇s movement performance and the P300 amplitude （ r = - 0.906, P 〈 0.01）. Conclusion Age and intelligence influenced the P300 as important facors, the abnormal P300 amplitude of DCD children demonstrated their motor control deficits.