重度子痫前期患者终止妊娠时间与母儿预后的相互关系

Analysis of 273 Maternal and Perinatal Prognosis Determined by the Time of Pregnancy Termination in Severe Pre-eclampsia

目的探讨重度子痫前期患者终止妊娠时间与母儿预后的相互关系。方法273例重度子痫前期患者按照确诊到终止妊娠的时间分组，〈24 h为A组（102例）、24-48 h为B组（66例）、〉48 h为C组（105例）。回顾性分析3组患者的临床资料。结果终止妊娠前低蛋白血症及蛋白尿的发生率3组间比较，差异有显著性（P〈0.05）；C组HELLP综合征的发生率低，与其他两组比较差异有显著性（P〈0.05）；3组胎儿发育受限和早产儿发生率比较，差异有显著性（P〈0.05）；3组分娩方式的比较差异有显著性，且剖宫产率均高于阴道分娩率（P〈0.05）。结论重度子痫前期患者应根据病情轻重、孕周、胎儿宫内状况，采取个体化的治疗方案，适时终止妊娠，能取得较好的预后。

Objective To investigate the optimal time of pregnancy termination for patients with severe pre-eclampsia. Methods A total of 273 cases with severe pre-eclampsia admitted. They were divided into three groups according to different time spans from confirmed diagnosis to delivery. Group A： within 24 hours; Group B： 24-48 hours; Group C： over 48 hours. Maternal and perinatal prognoses of the three groups were analyzed retrospectively. Results There was a remarked difference in the occurrence of low proteinumia and albuminuria before the termination of pregnancy（P〈0.05） ; A significant lower incidence of HELLP syndrome occurred in Group C than those in Group A and Group B（P〈0.05） ; The incidence of premature delivery showed obvious difference among the three groups（P〈0.05）;The method of delivery showed obvious diffevencc among the three groups （P〈0.05）. Conclusion Individualized treatment should be depended on patients＇ physical conditions,gestational ages and fetal states. Pregnancy should be terminated at its optimal time.