低毒性的纳米硒对顺铂抗肿瘤作用的影响

EFFECT OF ELEMENTAL SELENIUM AT NANO SIZE (Nano-Se) WITH LOWER TOXICITY ON THE ANTI-TUMOR EFFECT OF CISPLATIN

目的:研究低毒性纳米硒对顺铂抗肿瘤作用的影响。方法:小鼠灌胃纳米硒和亚硒酸钠,从致死、体重丢失和肝损伤方面比较毒性。小鼠补充纳米硒,给予不同剂量顺铂,从致死和体重丢失观察纳米硒的保护作用。小鼠接种肺癌细胞,用顺铂进行治疗,观察纳米硒的补充对顺铂治疗肿瘤作用的影响。结果:纳米硒毒性明显低于亚硒酸钠,降低了顺铂毒性,但不降低顺铂治疗肿瘤的作用。结论:低毒性纳米硒能改善顺铂治疗肿瘤的效果。

Objective： To investigate the effect of Nano-Se with lower toxicity on the anti-tumor effect of cisplatin, Method： For toxicity comparison, mice were orally administered Nano-Se and sodium selenite to observe death, body weight loss and liver injury. As to the protective effect of Nano-Se on the toxicity of cisplatin, mice with and without Nano-Se supplementation were injected cisplatin to observe death and body weight loss. For evaluation of whether Nano-Se influence the anti-tumor effect of cisplatin, Lewis lung carcinoma was transplanted into mice, and the survivor and tumor volume were recorded to compare the effect of Nano-Se supplementation on cisplatin. Results： The toxicity of Nano-Se is significantly lower than sodium selenite. Nano-Se can decrease toxicity of cisplatin without compromising its anti-tumor effect. Conclusion： Nano-Se with lower toxicity can improve the therapeutic effect of cisplatin.