摘要
目的:研究复方黄根对小鼠急性肝损伤的保护作用。方法:采用四氯化碳、D-氨基半乳糖盐酸盐诱导小鼠急性肝损伤模型,观察复方黄根对小鼠血清ALT、AST活性及肝组织匀浆SOD、MDA、GSH-PX水平的影响,并观察肝组织病理学改变。结果:复方黄根可明显降低小鼠血清中ALT、AST活性,同时能减少肝匀浆MDA含量,并能使降低的肝匀浆SOD、GSH-PX活性升高。结论:复方黄根有明显的保肝作用,其保肝作用与抗脂质过氧化有关。
Objective： To investigate the protective effect of Compound HuangC, en on acute liver injury in mice. Methods： The models of hepatic damage of acute were induced by CCL4, D -GAIN. The ALT, AST level in serum and MDA content, SOD, GSH - PX activites in liver homogenate, Pathology of liver were observed. Results： Compound HuangGen was found to significantly decrease the serum transaminase activities, Meanwhile Compound HuangGen also de- creased MDA content and prevented the reduction of SOD, GSH - PX activities in liver homogenate. Conclusion： Com- pound HuangGen show significant protective action on acute liver injury in mice.
出处
《中华中医药学刊》
CAS
2007年第11期2215-2217,共3页
Chinese Archives of Traditional Chinese Medicine
基金
广西科技厅科技攻关资助项目(桂科攻0235023-1桂科能0630006-5A)
关键词
复方黄根
急性肝损伤
保肝
compound HuangGen
acute liver injury
hepatoprotection
