慢性乙型肝炎的抗病毒治疗进展

Advance in the Antiviral Treatment for Chronic Hepatitis B

我国是乙肝病毒(HBV)感染的高发国,HBV感染易慢性化,部分病人发生肝硬化甚至肝癌.欲阻断其发展,抗病毒治疗是关键,只要存在适应证必须进行.尽管免疫机制在乙肝的发病中具有重要意义,但现行的免疫调节治疗均未取得满意疗效.抗病毒治疗迄今仍被认为是治疗乙型肝炎的最基本病因治疗.本文查阅近年来试用于临床抗病毒药物的使用情况,作一综述.

Infection rate of hepatitis B virus is very high in our country. The patient＇s condition tends to become persistent and maybe changes into cirrhosis of liver and liver cancer. Antiviral treatment can inhibit the deterioration of patient＇s condition if only the indications for this treatment exist. Although the immune mechanisms play an important role in the onset of hepatitis B the curative effect of immuno- regulation is not satisfactory and antiviral treatment is still regarded as etiological treatment for hepatitis B. This paper reviews the antiviral drugs and their application in clinical work in recent years.