摘要
灌胃牛角地黄冲剂，可明显抑制静注内毒素引起的动脉血压的降低，抑制血浆肿瘤坏死因子（ＴＮＦ）和组织因子（ＴＦ）含量的升高，提高其血浆组织因子途径抑制物（ＴＦＰＩ）／组织因子（ＴＦ）比值，并防止休克后血小板数和血浆抗凝血酶Ⅲ（ＡＴ－Ⅲ）活性的降低。
Anti shock of Niujao Dihuang granule was investigated by using E.coli endotoxic shock model in rats.Niujao Dihuang granule could markedly inhibited arterial pressure fall induced by injecting endotoxic intravenouly in rats(P<0 01),antagonize contents increase of plasma tumor necrosis factor(TNF) and tissue factor(TF) (P<0 05),enhance tissue factor pathway inhibitor(TFPI)/tissue factor(TF) ratio(P<0 05),and prevented decrease of platelet count and plasma anti thrombinⅢ(AT Ⅲ) activity (P<0 05) in shock rats.
出处
《中国实验方剂学杂志》
CAS
1997年第2期23-26,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
中药品
牛角地黄冲剂
内毒素休克
Niujao Dihuang granule,endotoxic shock,tumor necrosis factor(TNF),tissue factor(TF),tissue factor pathway inhibitor(TFPI)
