原发性高血压与α-adducin P460Trp突变的相关性研究

Association study between essential hypertension and α-adducin P460Trp mutation

目的:探讨原发性高血压与内收蛋白色氨酸突变(α-adducin P460Trp)是否相关。方法:高血压组与正常对照组各80例,均抽取外周血提取DNA,采用PCR方法检测是否存在P460Trp突变。比较两组α-adducin基因P460Gly基因型与P460Trp突变出现的频率的差异。结果:高血压组与对照组的P460Gly基因型与P460Trp突变出现的频率(52.5%对45%)并无显著差异。原发性高血压与α-adducinP460Trp突变并无显著相关性。原发性高血压同α-adducin蛋白460位基因型不存在特定联系。结论:在本研究人群中,α-adducin P460Trp突变与原发性高血压的发生不存在显著相关性。

Objective：To find whether there was linkage between essential hypertension and α- adducin P460Trp mutation in the population. Metbods： 80 hypertension patients and 80 controls were selected, we,recorded three BP values of different days for each patient and took the average value, PCR was used to test P460Trp mutation of both pateients and controls. Results：There was no significant difference of P460Trp mutation between hypertension patients and controls in the population （52.5% vs. 45%）. There was no linkage between essential hypertension and P460Trp mutation in the population. There was not significant linkage between essential hypertension and any gene type in the population. Conclusion：There is no linkage between essential hypertension and P460Trp mutation of α-adducin in the study.