T淋巴细胞及细胞因子与银屑病的发病关系

Relation of T lymphocytes and cytokines to psoriasis pathogenesis

近年来一些新的研究发现,银屑病患者外周血的T细胞表面的CD80和天然杀伤细胞受体的表达明显上调,单核细胞的活性也有所改变,而T细胞还可以影响正常皮肤的表皮通过时间,皮损中调节性T淋巴细胞亚群也有变化,白介素-23、20、19以及α-干扰素对银屑病的发病均有促进作用。一些新的免疫学研究发现,CD11a单抗、LFA-3/IgG1融合蛋白、TNF-α已经成为银屑病免疫治疗中较为成熟的疗法,而粒细胞-巨噬细胞集落刺激因子单抗IgG1,CD4单抗及补体受体3抗体的治疗作用在动物实验中已得到初步验证,有望为银屑病的治疗提供新的突破点。

Recently, some studies have revealed that there is an increased expression of CD80 and receptors of naturely killer cells on the surface of T lymphocytes in the periphery blood of psoriasis patients, and a change of monocyte activity and regulatory T lymphocytes subsets in psoriatic lesions. It is also found that T lymphocytes can affect the epidermal turnover time, and IL-23, IL-20, IL-19 and IFN-α all accelerate the pathogenesis of psoriasis. Now, CDlla monoclonal antibody, LFA-3/IgGl fusion protein and TNF-α - have been successfully applied in the immunotherapy of psoriasis, and animal experiments have primarily confirmed the therapeutic effects of anti-granulocyte-macrophage colony stimulating factor IgGl ,anti-CD4 monoclonal antibody and anti-complement receptor 3 antibody, which are hopeful to be the breakthrough of psoriasis treatment in the future.