单核细胞趋化蛋白-1与系统性红斑狼疮

Monocyte chemoattractant protein-1 and systemic lupus erythematosus

单核细胞趋化蛋白-1具有诱导单核细胞趋化和激活单核细胞的双重功效,在系统性红斑狼疮患者血清及尿液中均有高度表达,原因可能与其启动子基因多态性有一定关系。研究发现单核细胞趋化蛋白-1水平与系统性红斑狼疮患者病情活动有明确相关性。目前已开展有关针对单核细胞趋化蛋白-1在系统性红斑狼疮治疗方面的研究。

Monocyte chemoattractant protein-1 （MCP-1） can lead to the chemotaxis and activation of monocytes. There is a high level of MCP-1 in serum and urine of patients with systemic lupus erythematosus, which may be related to the polymorphism of MCP-1 promoter. It is revealed that the level of MCP-1 in the patients with systemic lupus erythematosus has certain correlation with the disease activity. The study has commenced about MCP-1 in systemic lupus erythematosus therapy.