特应性皮炎瘙痒机制的研究进展

Advances in pathogenesis of pruritis in atopic dermatitis

瘙痒是特应性皮炎的一个基本特征。因为瘙痒严重地影响着生活质量,大部分患者判断特应性皮炎的严重程度是通过瘙痒的剧烈程度而不是皮疹的表现。但其发生机制尚不完全清楚。最近,在研究特应性皮炎瘙痒的机制方面已取得很大的进展,既有神经系统的兴奋,又有一些介质的作用。这些进展为特应性皮炎患者瘙痒的研究和治疗提供新的思路。

Pruritus is an essential feature of atopic dermatitis. Because of its severe adverse effects on the quality of life, most of the patients evaluate the severity of atopic dermatitis by the intensity of pruritus rather than appearance of skin lesions. However, its mechanism is not completely understood. Recently, a considerable progress has been achieved in clarifying the complex pathogenesis of pruitus in atopic dermatitis, including the excitation of nervours system and the roles of several mediators. The recent knowledge about the mechanisms may offer new ideas for the treatment of itch in atopic dermatitis.