肠黏膜刷状缘中性氨基酸载体ASCT2的结构和功能特点

The neutral amino acid transporter ASCT2 in intestinal brush-border membrane:molecular and functional characteristics

ASCT2是肠黏膜刷状缘的一种Na+依赖性中性氨基酸载体,它的功能主要是转运中性氨基酸,如丙氨酸、丝氨酸、半胱氨酸、苏氨酸、谷氨酰胺和天冬酰胺等。对ASCT2分子结构、功能特点和调控特性等的研究,有助于对肠道功能的认识,并为临床短肠综合征(SBS)及其他肠功能障碍疾病提供新的治疗对策。

ASCT2 is a Na^＋ -dependent neutral amino acid transporter in brush-border membrane of intestinal epithelial cells. The activity accounts for the majority of intestinal luminal neutral amino acid absorption, such as alanine, serine, cysteine, threonine, glutamine, asparagine and so on. The study about molecular and functional characteristics of ASCT2 will help to the understanding of bowel function, and offer the potential for developing new treatments for short bowel syndrome and other bowel dysfunction conditions.