5Folkman J.What is the evidencr that tumors are angiogenesis dependent? J Natl Cancer Inst,1990,82:4-6.
6Weidner N,Semple JP,Welch WR,et al.Tumor Angiogenesis and metastasis-eorrelation in invasive breast carcinomar.N Engl J Med,1991,324:1-8.
7Ferrara N,Gerber HP,Lecouter J.The biology of VEGF and its receptors.Nat Med,2003,3:669-676.
8Kim KJ,Li B,Winer J,et al.Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo.Nature,1993,362:841-844.
9Ferrara N,Hillan KJ,Gerber HP,et al.Discovery and development of bevacizumab,an anti-VEGF antibody for treating cancer.Nat Rev Durg Discov,2004,3:391-400.
10Drevs J,Mdeinger M,Schmidt C,et al.Receptor tyrosine kinases:the main targets for new anticancer therapy.Curr Drug Targets,2003,4:113-121.
