牙源性透明细胞癌

Clear cell odontogenic carcinoma

为探讨牙源性透明细胞癌的临床病理学特性，用常规组织学及免疫组织化学法对３例牙源性透明细胞癌进行分析。发现该瘤主要由片状及小巢状排列的透明细胞构成，尚有少许基底样细胞。肿瘤无被膜，呈浸润性生长，上皮膜抗原及角蛋白阳性，增殖细胞核抗原染色见基底样细胞阳性率较透明细胞高。３例肿瘤中２例初次手术时即有局部淋巴结转移；另１例术后一年复发并发生淋巴结转移。结果表明，该瘤为恶性上皮性肿瘤，称之为牙源性透明细胞癌更符合其生物学特性。

Histopathologic and immunohistochemical features of 3 cases of clear cell odontogenic carcinoma were studied. The tumors were composed of sheets or islands of clear cells separated by mature collageneous tissue. Basaloid cells were also seen in the tumors. Tumor cells showed positive reactions for epithelial membrane antigen and cytokeratin. More PCNA positive cells were seen in basaloid cells than in clear cells. Metastasis to regional lymph nodes was found in all 3 cases.