乳腺癌微血管数与转移和预后的关系

The relationship between prognosis,metastasis and microvessel quantity in invasive breast carcinoma

目的探讨浸润性乳腺癌中微血管数（ＭＶＱ）与转移、预后的关系，ＭＶＱ与增殖细胞核抗原（ＰＣＮＡ）、ｃ－ｅｒｂＢ－２、ｎｍ２３－Ｈ１、组织蛋白酶Ｄ的关系。方法应用免疫组织化学ＬＳＡＢ法检测浸润性乳腺癌中ＭＶＱ与ＰＣＮＡ、ｃ－ｅｒｂＢ－２、ｎｍ２３－Ｈ１、组织蛋白酶Ｄ的表达。结果ＭＶＱ在７６例浸润性乳腺癌中的均数是５７．８２±２２．２２。ＭＶＱ与淋巴结转移、ｃ－ｅｒｂＢ－２、组织蛋白酶Ｄ（癌细胞）的表达无关；ＭＶＱ与远处转移（１０年内）、ＰＣＮＡ、组织蛋白酶Ｄ（间质细胞）表达呈正相关（Ｐ值均小于０．０１）；而与ｎｍ２３－Ｈ１、５年生存期呈负相关（Ｐ＜０．０１）。结论浸润性乳腺癌中ＭＶＱ与肿瘤的远处转移和生存期关系密切，可以作为一项独立的预后指标。

Objective To determine the prognosticvalue and relationship of microvessel quantity (MVQ)with PCNA,c erbB 2,nm23 H1 and Cathepsin D in invasive breast carcinoma.Methods Immunohistochemical techniques(LSAB)were used to detect the expression of PCNA,c erbB 2,nm23 H1,Cathepsin D and MVQ in 76 cases of invasive breast carcinoma.Results The mean of MVQ was 57.82±22.22 in 76 cases of invasive breast carcinoma.The expression of Cathepsin D(cancer cells),c erbB 2 and node positive were not related to MVQ.MVQ was positively correlated to expres sion of Cathepsin D(stroma cells),PCNA and distant metastasis(10 years),but negatively correlated to 5 year survival.Conclusion MVQ was significantly correlated to distant metastasis and survivalper oid in invasive breast carcinoma.MVQ may be an independant prognostic indicator.