鼻咽分泌物中β_2微球蛋白测定的临床意义

Clinical significance of beta 2 microglobulin content in nasopharyngeal secretion

为了探讨鼻咽分泌物中β２微球蛋白（β２－ｍｉｃｒｏｇｌｏｂｕｌｉｎ，β２－ＭＧ）含量的临床意义，以放射免疫法测定了７３例鼻咽癌患者、３０例慢性鼻咽炎患者和３０例健康人鼻咽分泌物β２－ＭＧ含量，并对３１例鼻咽癌患者作了治疗前后动态观察。结果发现：鼻咽癌组为４．８７±２．５１ｍｇ／Ｌ，慢性鼻咽炎组为１．０５±０．６４ｍｇ／Ｌ，对照组为０．８５±０．３２ｍｇ／Ｌ。鼻咽癌组明显高于鼻咽炎组与对照组，差异有显著意义（Ｐ＜０．０１）。在动态观察中发现放射治疗治愈组明显降低，放射治疗失败组仍增高。提示鼻咽部也具有β２－ＭＧ分泌功能，在患鼻咽癌时其水平升高，并与肿瘤的消长有一定相关性，其作为肿瘤标志物或病程转归判断指标的意义，值得进一步探讨。

To study its clinical significance, beta 2 microglobulin (β 2 MG) in nasopharyngeal secretion was examined using radioimmunoassasy methods in 73 patients with nasopharyngeal carcinoma (NPC) , 30 with chronic nasopharyngitis and 30 normal control subjects. In 31 NPC patients, the examination was repeated before and after radiotherapy. The average concentrations of β 2 MG were 4.87±2.51 mg/L in NPC group, 1.05±0.64 mg/L in chronic nasopharygitis group, and 0. 85±0. 32 mg/L in the control. The β 2 MG concentration was higher in the NPC patients than in both chronic pharyngitis patients and normal subjects ( P <0.01). The concentration was lowered down in NPC patients after radiotherapy, and remained high when the treatment failed to control the condition. It seems that β 2 MG level in nasopharyngeal secretion is closely related to the prognosis and recurrence of nasopharyngeal carcinoma.