当归对肝硬化犬门脉压力与胃粘膜血流的影响

Effects of Radix Angelicae Sinensis on Portal Pressure and Gastric mucosal Blood Flow in Cirrhotic Dogs

利用Bosch胆总管结扎法,建立犬肝硬化门脉高压模型,测定当归对犬门脉压力及胃粘膜血流的影响。结果静滴当归注射液后,肝硬化犬的门静脉压力(Ppv)、嵌塞肝静脉压(WHVP)、肝静脉压力梯度(HVPG)显著降低或极显著降低(P<0.05～0.01),平均动脉压(MAP)、心率(HR)无显著变化(P>0.05)。肝硬化犬的胃粘膜血流(GMBF)极显著低于正常犬(P<0.01)。用药10min后,肝硬化犬与正常犬的GMBF显著升高(P<0.05),60min后GMBF有所下降,但仍显著高于用药前(P<0.05)。

The models of hepatocirrhotic dogs were made by chronic bile duct ligation. The effects of Radix Angelicae Sinensis(RAS) of portal venous pressure and gastric mucosal blood flow(GMBF) in cirrhotic dogs were investigated. The results showed that, after administration of RAS by intravenous, the portal venous pressure (Ppv) , wedge hepatic venous pressure (WHVP) , hepatic venous pressure gradient (HVPG) of cirrhotic dogs were signficantly decreased(P<0. 05), but mean arterial pressure(MAP) and heart rate(HR) unchanged (P>0. 05). Before using drugs, the GMBF in cirrhotic dogs was lower than that in normal dogs (P<0. 01). Ten min after administration of RAS by intravenous, the GMBF in cirrhotic and normal dogs were significantly increased (P<0. 05). Sixty min later, the GMBF was decreased, but it was still higher than that before using drugs(P<0. 05).