天然自身抗体在清除凋亡细胞中的作用研究

The Effect of Natural Autoantibodies on the Elimination of Apoptotic Cells

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摘要凋亡每时每刻都在发生,对凋亡细胞的清除是免疫系统的基本功能,其中天然抗体发挥了重要的作用。天然抗体可以通过Fab部分结合凋亡细胞表面的LPC,LPC由PLA2水解凋亡细胞膜表面的PC形成。这种抗原抗体的结合可以激活补体C1q,进一步激活经典补体激活途径,于是补体C3b/bi在凋亡细胞表面沉积。巨噬细胞表面的CR3和CR4两个补体受体可以结合C3b/bi,完成对凋亡细胞的吞噬。所以天然抗体参与了凋亡细胞的吞噬,在避免凋亡细胞导致的自身免疫疾病的发生中可能具有重要的作用。 Apoptosis is happening all the time.The clearance of apoptotic cells is a basic function of immune system,among which natural autoantibodies play an important role.Natural antoantibody can combine LPC on the surface of apoptotic cells by Fab,which results from hydrolysis of PC on the surface of apoptotic cells by PLA2.This kind of antigen-antibody combination can activate complement C1q,which can activate classic complement activation pathway,so complement C3b/bi can deposit on the surface of apoptotic cells.Two complement receptor of CR3 and CR4 on the surface of macrophage can combine with C3b/bi and achieve the swallow of apoptotic cells.So natural antibodies take part in the swallow of apoptotic cells and play an important role in avoiding the genesis of antoimmune disease resulting from apoptotic cells.

作者尚婷婷李巍

机构地区第四军医大学西京医院皮肤科

出处《医学综述》 2007年第17期1283-1285,共3页 Medical Recapitulate

基金国家自然科学基金项目(30300318)

关键词天然抗体凋亡巨噬细胞补体 Natural autoantibody Apoptosis Macrophages Complement

分类号 R392.12 [医药卫生—免疫学]

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1Aliprantis AO,Yang RB,Mark MR,et al.Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2[J].Science,1999,285(5428):736-739.
2Kim SJ,Gershov D,Ma X,et al.I-PLA(2)activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunogobulin M antibodies and complement activation[J].J Exp Med,2002,196(5):655-665.
3Fhrenstein MR,Cook HT,Neuberger MS.Deficiency in serum immunoglobulin(Ig)M predisposes to development of IgG autoantibodies[J].J Exp Med,2000,191(7):1253-1258.
4Carroll MC.A protective role for innate immunity in systemic lupus erythematosus[J].Nat Rev Immunol,2004,4(10):825-831.
5Lacroix-Desmazes S,Kaveri SV,Mouthon L,et al.Self-reactive antibodies(natural autoantibodies)in healthy individuals[J].J Immunol Methods,1998,216(1-2):117-137.
6Quintana FJ,Cohen IR.The natural autoantibody repertoire and autoimmume disease[J].Biomed Pharmacother,2004,58(5):276-281.
7Lauber K,Bohn E,Krober SM,et al.Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal[J].Cell,2003,113(6):717-730.
8Boes M.Role of natural and immune IgM antibodies in immune responses[J].Mol Immunol,2000,37(18):1141-1149.
9Shi Y,Evans JE,Rock KL.Molecular identification of a danger signal that alerts the immune system to dying cells[J].Nature,2003,425(6957):516-521.
10Boes M,Schmidt T,Linkemann K,et al.Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgG[J].Proc Natl Acad Sci UsA,2000,97(3):1184-1189.

1矫文捷,陈玉平,李文,区颂雷,石镜,张志泰.猪人异种移植超急性排斥反应补体激活途径的探讨[J].中国免疫学杂志,2000,16(2):95-95.
2吴春风,马忠森,王秀丽,杨俊玲,杨洋,张越,图们乌力吉,乔俊华.抗人DcR3单克隆抗体的研制及其鉴定[J].细胞与分子免疫学杂志,2008,24(2):139-141. 被引量：2
3于江,山长武.正常人红细胞免疫功能的初步研究[J].济宁医学院学报,1993,16(2):24-25.
4尹迪,徐凤花,戚中田.补体C3d作为分子佐剂的研究进展[J].中国肝脏病杂志（电子版）,2008(2):57-59. 被引量：1
5李健敏(综述),赵书平(审校).补体调节蛋白CD59与肿瘤[J].国际肿瘤学杂志,2009,36(12):897-899.
6免疫分子生物学(免疫化学)[J].国外科技资料目录（医药卫生）,2000(1):6-7.
7免疫分子生物学(免疫化学)[J].国外科技资料目录（医药卫生）,1997(6):13-15.
8免疫分子生物学(免疫化学)[J].国外科技资料目录（医药卫生）,1997(8):16-20.
9吴春风,马忠森,王秀丽,杨俊玲,杨洋,张越,图们乌力吉,乔俊华.人DcR3融合蛋白的表达、纯化及多克隆抗体的制备[J].细胞与分子免疫学杂志,2007,23(12):1160-1162. 被引量：2
10李文君,陈政良.CR3的分子生物学[J].国外医学（分子生物学分册）,2002,24(1):32-34.

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天然自身抗体在清除凋亡细胞中的作用研究

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