摘要
目的观察131I-17-丙烯胺基-17-脱甲基格尔德霉素(131I-17-AAG)治疗VX2肝癌移植瘤模型的骨髓及肝脏毒副作用。方法16只新西兰白兔,制成VX2荷肝癌模型后,按完全随机原则分为2组,1组(治疗组)8只,10mCi131I-17-AAG耳缘静脉注射;2组(对照组)8只,为未经治疗的荷瘤兔,1、2组荷瘤兔均分别于第1、2周耳缘静脉采血,进行血常规(白细胞、红细胞、血红蛋白、血小板)及酶学(谷草转氨酶、谷丙转氨酶、碱性磷酸酶、谷氨酰转酞酶)检查。结果2周时白细胞、红细胞和血红蛋白无显著差异(P>0.05),血小板、ALT、AST均有显著差异(P<0.05),碱性磷酸酶、谷氨酰转移酶无显著差异(P>0.05)。结论131I-17-丙烯胺基17脱甲基格尔德霉素(131I-17-AAG)对骨髓造血干细胞及肝功能各项指标有不同程度的影响,且随时间逐步得到恢复。
Objective To investigate the bone marrow side-effect and liver toxicity of the treatment on vx2 transplanted liver cancer model rabbits with 17-allylamino-17-demethoxygeldanamycin. Methods 16 New-Zealand white rabbits were made into VX2 transplanted liver cancer models and devided into two groups randomly. 8 rabbits in the first group (treatment group) were treated with 10 mCi ^131I-17-allylarnino-17-demethoxygeldanamycin by ear vein injection, and the second group(contrast group) was untreated. 1 week and 2 weeks after injection two groups were examined of white blood cells (WBC), red blood cells (RBC), blood platelet (PLT), hemoglobin (Hb), glutamate-pyruvate transaminase(ALT), glutamic-oxal (o) acetictransaminase (AST) alkaline phosphatase(ALP) 7-glutamyltransferase(GGT). Collected data were analyzed with SPSS14. 0. Results The variance of white blood cells(WBC), red blood cells(RBC), hemoglobin(Hb), alkaline phosphatase (ALP), γ- glutamyltransferase (GGT) were nonsignificant ( P 〉 0.05 ) in 2 weeks. However, the significance of variance was seen in blood platelet(PET), glutamate-pyruvate transaminase(ALT), glutamic-oxal (o) acetic transaminase (AST) at the same time ( P 〈 0.05). Conclusion The side-effects of 131I-17-allylamino-17-demethoxygeldanamycin differed in various blood items and improved with time.
出处
《实用临床医药杂志》
CAS
2007年第5期59-61,共3页
Journal of Clinical Medicine in Practice
基金
国家自然科学基金资项目(30470500)
江苏省科技厅社会发展指令性计划(BS2004020)