摘要
以甲苯为溶剂及带水剂,用粉末K2CO3代替常规使用的乙醇钠,在季铵盐和聚乙二醇混合相转移催化剂的存在下,含有活泼氢的丙二酸二乙酯和氰乙酸乙酯与二卤代物进行缩合反应,得到相应的环化物。该方法与传统的乙醇钠法相比,操作更简单,反应时间缩短,产率得到很大的提高。
Cycloalkylation of diethyl malonate and ethyl cyanoacetate with alkyl halide was investigated in the presence of toluene.During this reaction,quaternary ammonium halide and polyalkylene glycol were used as the phase-transfer catalyst and anhydrous potassium carbonate powder was used as the base.The yield was improved significantly,the reaction time was reduced,and the preparation procedure was simpler compared with the traditional process.
出处
《化学试剂》
CAS
CSCD
北大核心
2007年第11期681-683,共3页
Chemical Reagents
关键词
丙二酸二乙酯
氰乙酸乙酯
碳酸钾
相转移催化剂
甲苯
diethyl malonate
ethyl cyanoacetate
potassium carbonate
phase-transfer catalyst（PTC）
toluene
