应用Vilsmeier反应合成对氨基苯乙炔

The synthesis of 4-ethynylaniline via Vilsmeier reaction

以对硝基苯乙酮为原料,应用Vilsmeier反应构建含取代烯键的分子,经水解、消除反应得到对硝基苯乙炔,用锌粉还原得到对氨基苯乙炔。对制得的对氨基苯乙炔进行了结构分析,并测定了含量,表明该路线是合成对氨基苯乙炔的较好方法,收率、含量均较高。同时也为其他苯乙炔衍生物的合成提供了借鉴。

4-Ethynylaniline was prepared from p-nitroacetophenon via the Vilsmeier reaction.The result indicated that this route is characterized by both nice yield and high purity.This method is a good route to synthesis 4-ethynylaniline,and it is also a good route for synthesizing other phenylacetylene derivates.