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大鼠鞘内注射哇巴因及混合新斯的明的抗伤害作用 被引量：1

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摘要 [目的]探讨大鼠鞘内注射哇巴因、新斯的明以及两者混合的抗伤害作用。[方法]SD大鼠鞘内埋入导管并留置。经导管分别将哇巴因、新斯的明、哇巴因混合新斯的明注入鞘内。以甩尾反应阈值为观察指标,观察注药前后的抗伤害效应效果。[结果]大鼠鞘内单独注射新斯的明(0.05～3μg)和哇巴因(1～5μg)产生剂量依赖性的抗伤害作用。大鼠鞘内注射哇巴因(1μg)能增强新斯的明(0.3μg)的抗伤害作用。其抗伤害作用可被鞘内注射阿托品所拈抗。[结论]大鼠鞘内注射哇巴因能增强新斯的明的抗伤害作用。
作者 曾维安 何伟雄 陈祥楠 欧阳汉栋 李强
机构地区 华南肿瘤重点实验室//中山大学附属肿瘤医院麻醉科
出处 《中山大学学报（医学科学版）》 CAS CSCD 北大核心 2007年第B06期1-3,共3页 Journal of Sun Yat-Sen University:Medical Sciences
基金 国家自然科学基金项目(30571794/C03030301)
关键词 新斯的明 哇巴因 鞘内注射 抗伤害作用
分类号 R614 [医药卫生—麻醉学]
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参考文献10

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共引文献3

同被引文献9

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中山大学学报（医学科学版）
2007年 第B06期

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