UPPP手术对阻塞性睡眠呼吸暂停低通气综合征患者血清hs-CRP的影响

Effect of uvulopalatopharyngoplasty on high sensitive C-creative protein in the serum of patients with obstructive sleep apnea hypopnea

目的探讨悬雍垂腭咽成形术(uvulopalatopharyngoplasty,UPPP)对阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrom,OSAHS)患者血清超敏C-反应蛋白(high sensitive C-creative protein,hs-CRP)的影响。方法选择20例OSAHS患者,先后进行UPPP手术,术前均被抽取晨起血清,检测hs-CRP。术后3个月再次测量血清hs-CRP,同时设立两对照组进行对照研究。结果OSAHS患者术前的血清hs-CRP水平明显高于两个对照组(P<0.05),术后3个月明显降低。结论hs-CRP可以作为预测此类患者发生心血管疾病的指标,而UPPP手术可以降低OSAHS患者血清hs-CRP水平,从而减少OSAHS患者心血管疾病的发病率。

Objective To explore the effects of uvulopalatopharyngoplasty（UPPP） on high sensitive C-creative protein（hs-CRP） in serum of patients with obstructive sleep apnea hypopnea syndrome（OSAHS）. Method Before and three months after the operations, serum hs-CRP was detemained in the experimental group （ n = 20） and two control groups. Result The serum level of hs-CRP in OSAHS patients was significantly higher than that of the control groups and it was significantly decreased three months after UPPP. Conclusion UPPP can obviously decrease the level of hs- CRP of OSAHS patients; therefore it reduces the incidence of cardiovascular disease of OASHS patients.