摘要
雌激素与老年性耳聋的关系正逐渐受到重视,但其发病机制尚不很清楚,本文主要综述雌激素对神经元的保护作用及其与老年性耳聋的相关性,探讨雌激素减少可能介导的老年性耳聋的发病机制。
出处
《山东大学耳鼻喉眼学报》
CAS
2007年第5期427-429,共3页
Journal of Otolaryngology and Ophthalmology of Shandong University
基金
福建创新人才科研基金2004J047
参考文献27
-
1Gates G A,Mills J H.Presbycusis[J].Lancet,2005,366(9491):1111-1120.
-
2Spicer S S,Schulte B A.Pathologic changes of presbycusis begin in secondary processes and spread to primary processes of strial marginal cells[J].Hear Res,2005,205(1-2):225-240.
-
3Ichimiya I,Suzuki M,Mogi G.Age-related changes in the murine cochlear lateral wall[J].Hear Res,2000,139:116-122.
-
4Yamasoba T,Someya S,Yamada C,et al.Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss[J].Hear Res,2006,226:185-193.
-
5Stenberg A E,Wang H,Fish J 3rd,et al.Estrogen receptots in the normal adult and developing human inner ear and in Turner's syndrome[J].Hear Res,2001,157:87-92.
-
6Stenberg A E,Simonoska R,Stygar D,et al.Effect of estrogen and antiestrogens on the estrogen receptor content in the cochlea of ovariectomized rats[J].Hear Res,2003,182:19-23.
-
7Sohrabji F,Miranda R,Toran-Allerand C D.Identifcation of a putative estrogen response element in die gene encoding brain-derived neurotrophic factor[J].Proc NatlAcadSci USA,1995,92:11110-11114.
-
8Dong L,Wang W,Wang F,et al.Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells[J].J Biol Chem,1999,274:32099-32107.
-
9Garcia-Segura L M,Cardona-Comez P,Naftolin F,et al.Estradiol upregulates bcl-2 expression in adult brain neurons[J].Neuroreport,1998,9:595-597.
-
10Merry D E,Korsmeyer S J.Bcl-2 gene family in the nervous system[J].Arm Rev Neurosci,1997,20:245-267.
二级参考文献10
-
1Cuzzocrea S, Mazzon E, DugoL, et al.A role for superoxide in gentamicin- mediated nephropathy in rats [J] .Eur J Pharmacol, 2002,450 (1): 67~76.
-
2Otte J, Sohuknecht HF. Ganglion cell populations in normal and pathological human Cochleae. Implications for cochlear implantation [J].Laryngoscope, 1988, 78: 1231~1246.
-
3Sone M, Schachern PA, Paparella MM.Loss of spiral ganglion cells as primary manifestation of aminoglycoside ototoxicity [ J ] . Hear Res1998; 115: 217-223.
-
4Waters C.Molecular mechanisms of cell death in the ear [J] .Ann N Y Acad Sci, 1999, 884: 41-51.
-
5Sakac V, Sakac M.Free oxygen radicals and kidney diseases - part Ⅰ[J] .MedPregl, 2000, 53 (9-10): 463-474.
-
6Nakagawa T, Yamane H, Takayama M, et al. Apoptosis of guinea pig cochlear hair cells following chronic aminogycoside treatment [J] . Eur Arch Otorhinolaryngol, 1998, 255 (3): 127- 131.
-
7Chen XC, Zhu YG, Mu LA, et al. Ginsenoside Rgl attenuates dopamine- induced apoptosis in PC12 cells by suppressing oxidative stress [J] .EurJ Pharmacol.2003, 473 (1): 1-7.
-
8Popa R, Anniko M, Takumida M, et al. Localization of nitric oxide synthase isoforms in the human cochlea [J] .Acta Otolaryngol, 2001,121 (4): 454 - 459.
-
9Pai N, Zdanski CJ, Gregory CW, et al. Sodium nitroprusside/nitric oxide causes apoptosis in spiral ganglion cells [ J] . Otolaryngol Head Neck Surg. 1998, 119 (4): 323-330.
-
10王大君,韩东一,杨伟炎,姜泗长.碱性成纤维细胞生长因子对耳蜗螺旋神经节细胞谷氨酸钠毒性作用的影响[J].中华耳鼻咽喉科杂志,1998,33(3):165-168. 被引量:12
共引文献10
-
1汪晓锋,林昶,程金妹.ABAD、雌激素受体、bcl-2、Bax在小鼠内耳中的表达差异[J].中华耳科学杂志,2008,6(4):454-458. 被引量:3
-
2顾晰,林昶,张榕.耳毒性药物致耳蜗螺旋神经节细胞损伤机制[J].国际耳鼻咽喉头颈外科杂志,2008,32(6):328-330.
-
3顾晰,林昶,张榕.庆大霉素对小鼠耳蜗螺旋神经节细胞损伤机制初步研究[J].中华耳科学杂志,2009,7(3):256-260. 被引量:3
-
4钟萍,田理.老年性听力损失的中西医研究近况[J].中医临床研究,2010,2(19):117-119.
-
5GU Xi LIN Chang ZHANG Rong.A study of gentamicin injury mechanisms using cultured mouse cochlear spiral ganglion cells[J].Journal of Otology,2011,6(1):31-35. 被引量:1
-
6宝东艳,王爱梅,李伟红,卢伟.丹参对庆大霉素致豚鼠螺旋神经节毒性的拮抗作用[J].中国老年学杂志,2013,33(4):873-875. 被引量:2
-
7崔勇,何亚,武瑾,米文娟,何端军,张力鸥,邱建华.Mn-SOD在螺旋神经节区域分布差异与噪声性听力损伤的关系[J].中华耳科学杂志,2013,11(1):107-111. 被引量:6
-
8赵振鹿,乔月华,丛涛,李兴启,杨仕明,赵立东.耳蜗螺旋神经节细胞的损伤和再生[J].中华耳科学杂志,2016,14(1):43-48. 被引量:4
-
9王淑芳,张莉,李国慧,张雯雯,王亚平,耿斌.围绝经期女性良性阵发性位置性眩晕患者雌孕激素水平和血钙浓度的变化[J].中华耳鼻咽喉头颈外科杂志,2017,52(4):287-290. 被引量:34
-
10于姝媛,李浩楠,朱紫嘉,王苹,杜波.红景天苷通过降低氧化应激介导氨基糖苷类药物耳毒性的抑制作用[J].中国听力语言康复科学杂志,2018,16(4):246-249. 被引量:5
同被引文献14
-
1卜行宽.认真贯彻WHO关于发展中国家助听器及其服务指南精神 做好我国的助听器服务工作[J].听力学及言语疾病杂志,2005,13(1):1-2. 被引量:13
-
2戴德.氧自由基与氨基糖苷类抗生素致听觉损害的相关性研究[J].现代预防医学,2005,32(5):427-428. 被引量:11
-
3王苹,汤勇,杜波,杜宝东,肖北春.钙蛋白酶和钙蛋白酶抑素在老年聋大鼠耳蜗中的表达[J].中国老年学杂志,2006,26(10):1397-1399. 被引量:6
-
4谢静,龚树生.衰老与老年性耳聋[J].国际耳鼻咽喉头颈外科杂志,2006,30(6):367-370. 被引量:8
-
5Bess FJ,Lichtenstein MJ,Logan S,et al.Heating impairment as a determinant of function in the elderly[J].J Am Geriatric Soc,1989,37:123.
-
6De Rivera C,Shukitt-Hale B,Joseph J A,et al.The effects of antioxidants in th-e senescent auditory cortex[J].Nenrobiol of Aging,2006,27:1035-1044.
-
7Nakagawa T,Kim TS,Mural N,et al.A novel technique for inducing local inn-er ear damage.Hear Res,2003,176(1-2):122-127.
-
8Bartus RT,Elliott PJ,Hayward NJ,et al Calpain as a novel target for treating a-cute neurodegenerative disorders[J].Neurol Res,1995,17(4):249-58.
-
9Takumida M,Anniko M.Radical scavengers:a remedy for presbyacnsis.A pil-ot study.Acta Otolaryngol,2005,125(12):1290-1295.
-
10Eric C Bielefeld,Donald Coling,Guang-Di Chen and Donald Henderson.Multiple dosing strategies with acetyl L-carnitine(ALCAR)fail to alter age-relat-ed hearing loss in the Fischer 344/NHsd rat[J].Journal of Negative Results in BioMedicine,2008,7:4.