摘要
目的:考察替硝唑葡萄糖注射液(200ml葡萄糖11g和替硝唑0.4g)在配制环节上的最佳条件及中间体pH值控制范围.方法:在三种不同配制条件下配制替硝唑葡萄糖注射液,并将pH值分别调至4.0、4.2、4.4、4.6、4.8,经灭菌冷却后分别测定成品的有关物质.结果:煮沸时间长短及pH值大小对替硝唑葡萄糖注射液成品有关物质有较大影响.结论:采用加完替硝唑后不再煮沸的配制方法,中间体pH值控制在4.0—4.2之间.
Objective: In order to find out the best condition, this experiment studied the technologic and pH of middle production for Tinidazole glucose injection(specification:Tinidazole 0.4g and llg in 200ml).Methods: Use three methods to cotect tinidazole glucose injection and control it's pH at 4.0,4.2,4.4,4,6,4,8.After it's being heated to be sterilized, check the product's impurity.Results: The time of it's boiling and the pH are the important effects. Conclusion: Use the method of stopping boiling after adding tinidazole and the pH of intermediate product should be controled at 4.0-4.2.
出处
《黑龙江医药》
CAS
2007年第6期599-600,共2页
Heilongjiang Medicine journal
关键词
替硝唑葡萄糖注射液
有关物质
Tinidazole glucose injection
Concerned substances