狼疮性肾炎患者血清生长激素检测的意义

The Measurement and Clinical Significance of Serum Growth Hormone in Patients with Lupus Nephritis

目的:探讨生长激素(GH)与狼疮性肾炎(LN)的关系。方法:采用放射免疫分析法(RIA)检测52例LN患者和30例健康体检者血清GH水平。结果:LN组血清GH水平明显高于正常对照组(P<0.05);活动期LN组GH水平显著高于静止期LN组(P<0.05);52例LN患者血清GH水平与抗ds-DNA水平呈正相关(r=0.713,P<0.05)。结论:LN患者血清GH水平与病情活动有关,可将GH作为判断LN病情活动性的指标之一;GH在LN发病中可能起一定的作用。

Objective： To investigate the relationship between growth hormone（GH） and Lupus Nephritis（LN）. Methods：Serum GH levels were determined in 52 LN patients and 30 matched healthy controls by automated chemiluminescence＇s system. Results： The mean serum GH levels were significantly higher in LN patients than those in healthy controls（P〈0.05）, and the GH levels were significantly higher in active group than those of inactive group（P〈0.05） . Serum G H levels of 52 LN patients were positively correlated with anti-ds-DNA levels（r= 0. 713, P〈 0.05）. Conclusion：The results suggest that elevated serum GH correlates with active disease in LN which indicates GH might participate in the pathogenesis of LN and serum GH could be a useful marker for disease activity in LN.