趋化素样因子-1在狼疮性肾炎患者肾组织中的表达

Expression of chemokine like factor-1 in nephridial tissue of lupus nephritis

目的:探讨趋化素样因子-1(chemokine like factor-1,CKLF-1)在狼疮性肾炎的发生、发展过程中的作用。方法:对34例确诊为狼疮性肾炎以及10例对照组患者的肾组织进行免疫组织化学染色,在光镜下观察肾小球CKLF-1阳性细胞率和CKLF-1阳性肾小管百分率及反应强度。结果:狼疮性肾炎患者的肾小球CKLF-1阳性细胞率和CKLF-1阳性肾小管百分率分别为10.4%±1.5%和48.9%±4.3%,与对照组患者4.6%±1.1%和4.3%±0.9%比较均有统计学差异(P<0.01)。CKLF-1在狼疮性肾炎患者的肾小球阳性细胞率和阳性肾小管百分率与狼疮性肾炎活动指数间均存在显著相关性,相关系数分别为0.74和0.53(P<0.05)。结论:CKLF-1参与了狼疮性肾炎的发生、发展过程。

Objective To investigate the influence of chemokine like factor-1 （ CKLF-1 ） on the genesis and devolopment of lupus nephritis. Methods Immunohistochemistry stain was employed on the 34 lupus nephridial tissues and 10 nephridial tissues of control group. And light microscopy was applied to observe the percentage of CKLF-1 positive cells of renal gromerulus and tubule. Resuits The percentages of CKLF-1 positive cells of renal gromerulus and tubule were 10.4% ± 1.5% and 48. 9% ± 4. 3% in the lupus nephritis group, and the percentages of control group were 4.6% ±1. 1% and 4. 3% ± 0. 9%. There was significant difference between 2 groups （P 〈 0.01）. And there was positive correlation between the percentage of CKLF-1 positive cells of renal gromerulus and tubule and lupus active index （ r = 0.74 and r = 0.53 , respectively, P 〈 0.05 ）. Conclusion CKLF-1 plays a role in the genesis and development of lupus nephritis.