硫酸羟氯喹中残留有机溶剂的顶空毛细管GC法测定

Determination of Residual Organic Solvents in Hydroxychloroquine Sulfate by Capillary GC with Headspace Injection

硫酸羟氯喹(hydroxychloroquine sulfate,1)用于治疗盘状红斑狼疮和系统性红斑狼疮。1在合成过程中使用了乙醇、二氯甲烷、正己烷、乙酸乙酯等有机溶剂。本研究采用顶空毛细管GC法,以苯为内标,测定上述各有机溶剂的残留量。

A temperature programmed capillary GC method with headspace injection was established for the determination of residual organic solvents-ethanol, dichloromethane, n-hexane, ethyl acetate in hydroxychloroquine sulfate, using DMF as solvent and benzene as internal standard. The average recoveries of the organic solvents were 96.4%, 99.5%, 95.8% and 95.1%. resoectively.