氟伏沙明与氯丙咪嗪治疗强迫症的对照研究

A control study of fluvoxamine and chlormipramine in treatment of obsessive compulsive disorder.

目的比较氟伏沙明和氯丙咪嗪治疗强迫症的疗效和不良反应。方法用CCMD-3作为诊断标准，用Yale—Brown强迫量表和TESS量表评定临床疗效和不良反应，对59例强迫症患者进行随机双盲的8周治疗。结果氟伏沙明有效率为70．2％，与氯丙咪嗪60，7％相近，两者无显著差异。氟伏沙明不良反应发生率36．7％，明显少于氯丙咪嗪75．0％，两者有明显差异。结论氟伏沙明治疗强迫症，疗效与氯丙咪嗪相当，不良反应较轻，耐受性好。

Objective To compare the efficacy and adverse effects of fluvoxamine and chlormipramine in treating patients with obsessive compulsive disorder. Methods According to CCMD - ill, 59 patients with obsessionwere randomly divided into fluvoxamine group and chlormipramine. The duration of treatment was 8weeks. Yale - Brown scale and TESS were used to evaluate the efficacy and adverse effects respectively. Results The effective rates of fluvoxamine group and chlormipramine were 70.2 % and 60.7 %, whichshowed no significant difference between the two groups. The occurred rate of adverse effects of fluvoxamine decreased significantly than that of chlormipramine 36.7%, 75.0% respectively. Conclusions Fluvoxamine has more efficacy than chlormipramine , but has less adverse effects in treatment of obsession.