摘要
目的 观察联合β受体阻滞剂美托洛尔治疗慢性充血性心力衰竭（CHF）的临床疗效及安全性。方法 选择慢性充血性心力衰竭患者54例，根据治疗情况随机分成两组，常规治疗组24例给予内科常规抗心力衰竭治疗，实验组30例在常规治疗的基础上加用美托洛尔治疗．治疗前后观察静息心率（HR）、收缩压（SBP）、舒张压（DBP）、心功能级别、左室舒张末内径（LVEDD）、左室射血分数（LVEF）、心脏指数（C1）及血浆脑钠肽（BNP）水平．结果 两组患者的各项指标在治疗后均较治疗前有明显改善，但实验组较常规治疗组改善更为显著，其临床疗效优于常规治疗组（P〈0．05）。结论 在常规抗心衰治疗基础上加用美托洛尔可明显改善患者心功能，是一种安全、有效的临床治疗方法。
Objective To study the clinical effects of metoprolol for congestive heart failure. Methods Fifty - four patients with congestive heart failure （cardiac function NYHA Ⅱ -Ⅲ class）were divided randomly into two groups： treatment greup （30 cases） and control group （24 cases）The routine therapy for the two groups were same, the difference only was that for the treatment group, metoprolol was added. The observable factors such as heart late, systolic blood pressure, diastolic blood pressure,heart functional class,left ventricle end - diastole diameter, left ventricle ejection fraction, cardiac index and so on, were collected for both groups. Results After treatment, the observable factors in both groups were improved magnificently. However the improvement m the treatment group was markedly superior to the control group （ P 〈 0. 05）. Conclusion Metoprolol is an effective medicine for congestive heart failure on the basis of routine therapy.
