乙肝后肝硬化患者内源性一氧化氮水平与临床表现的关系

The relationship between the production of endogenous nitric oxide and clinical symptoms in patients with cirrhosis post hepatitis B

目的探讨肝硬化患者体内一氧化氮（NO）产生量与临床表现的关系。方法以Rivonal反应法检测血浆NOZ，评估NO产量，同时检测患者肝功、电解质、尿钠，对结果进行统计学分析。结果各组肝硬化患者血浆NO2-含量均高于对照组（分别为P＜0．05和P＜0．01），但与肝功各指标无相关性。高NO2-组平均动脉压、尿钠显著减少（P＜0．01），腹水、功能性肾衰发生率明显增加（P＜0．01和P＜0．05）。结论肝硬化时NO合成增加并可能介导高动力循环，从而引起腹水、浮肿等并发症。

Objective To reaserch the relationship between the production of the nitric oxide (NO)and the clinical symptoms in patients with cirrhosis post hepatitis B.Method To eveluate the re1alionship between the production of NO and clinical behavior,the 1evel of Plasma NO2-was measured by Rivonal reaction. Meanwhle the liver function, blood electrolyte and natriuresis were measured.The results were anlysized by statistic method.Results The plasma NO,increased obviously in the patients compared with control group, and correlation didn't appeared between NO2-and the indexes of live function. In Patients with high NO2-group, the'mean artery pressure and urine natrium obviously decreased (P<0. 01), the accidence rate of ascited and functional renal failure were higher (P<0.01 and P<0.05).Conclusion Synthetic quantity of endogenous NO was numerous and it might induce the hyperdynamic circulation and develop of some complications such as ascited and renal failure in patients with cirrhosis.