肝纤维化指标联合检测在肝病诊断中的临床应用

Clinical value of combined determination of three hepatofibrosis indexes for liver diseases

目的探讨肝纤维化指标联合检测在肝病中的应用价值。方法采用放免法对144例肝病患者进行IV－C、HA、LN检测，并与30例献血员作对照组．统计学处理采用t检验和X2检验。结果重症肝炎、肝炎肝硬化血清IN-C、HA和LN水平和慢性肝炎（中、重度）患者血清IV—C和HA较对照组均明显升高（P＜0．001），肝硬化较慢性肝炎（中、重度）3项肝纤维化指标明显升高（P＜0．05）。肝硬化、重型肝炎和慢性肝炎（中、重度）3项指标同时检出率分别为88．9％、80％和70．8％。结论血清W—C、HA、LN联合检测对肝病的诊断及预后的判断有重要意义。病毒性肝炎患者肝纤维化血清学指标3项同时超过正常上限时，即应抗肝纤维化治疗。

Objective To research the clinical value of hepetofibrosis indexesfor diagnosis and treatment of liver diseases.Methods The serum leveIs of type IV collagen (lV-C), hyaluronicacid (HA) and fandnin (LN)were measured using radioinununoassay in 144Patients with various liver diseases, 30 blood donors were studtal ascontrols. The t test and chrtquare test were used for stutisticalanalysis.Rcsults The levels of IV -C' HA and LN In postchepatitis clerhosisand severe hepahtis, and the levels of Wed and HA in chronichepahtis (middle and severe degree) were significanhy higher thanthat in control group(P<0.001). The positive rates of threehepatofibrosis indexes determinied simultaneously were 88.9% 80%and70.8% respehvely, in postchepahtis cirrhosis, severe hepahtis andchroulc hepatitis (middle and severe degreeConclusions The combined detendnation of IV-C, HA and LN hasimportant clinical value in determining severity of hepatic damage anddiagnosis of cirrhosis. The anti-hepatofibrosis treatment should begiven if all of three hepatofibrosis indexes get above upper limit of normal in viral hepatitis patients.