HIV蛋白酶及其抑制剂

Recent Advances in HIV Protease Inhibitors

ＨＩＶ蛋白酶是病毒复制必需酶，是寻找治疗获得性免疫缺陷病药物的重要靶点之一。根据该蛋白酶的生理、生化性质、空间结构和底物的特点，合理设计并合成和筛选抑制剂，已成为当前抗ＡＩＤＳ药物研究的热点。本文综述这方面的研究进展。

HIV Protease plays a crucial role in HIV replication and maturation. Inhibition of this enzyme leds to the formation of noninfectious progeny virus in vitro.Its inhibitors were widely studied for chemotherapeutic agents in the treatment of AIDS. The accumulative knowledge about physiology, chemistry, steric structure and substrate specificity of the enzyme facilitated the design discovery of its inhibitors. Three compounds have been authorized as the clinical drugs till now. This review aims to summarize progresses of this research in the past years.