五味子宁神口服液的镇静及催眠作用研究

Study on the Sedative and Hypnotic Effects of Wuweizi Ningshen Oral Liquid

目的对五味子宁神口服液的镇静、催眠、抗惊厥药理作用进行初探。方法采用镇静、催眠、抗惊厥实验观察五味子宁神口服液对小鼠自主活动的影响,协同戊巴比妥钠对小鼠的催眠作用及对小鼠尼可刹米惊厥的抑制作用。结果五味子宁神口服液能明显减少小鼠自主活动次数,增加阈下剂量戊巴比妥钠致小鼠睡眠只数,延长阈上剂量戊巴比妥钠致小鼠睡眠时间,延长小鼠发生惊厥的潜伏期及减少小鼠死亡只数。结论五味子宁神口服液有明显的镇静、催眠、抗惊厥作用。

Objective To make a preliminary study on the sedative, hypnotic and anti - convulsion effects of Wuweizi Ningshen Oral Liquid. Methods The effects of Wuweizi Ningshen Oral Liquid on sedation, hypnotics and anti - convulsion in mice were observed by counting spontaneous behavior,prolonging sleeping time cooperated with pentobarbital sodium and antagonizing convulsion induced by Nikethamide injection. Results The results showed that Wuweizi Ningshen Oral Liquid could markedly inhibit spontaneous motion, enhance the sleeping number of pentobarbital sodium （subthreshold dosage ）, prolong the sleeping time of pentobarbital sodium（ superthreshold dosage） and prolong the convulsion time and decrease death number of mice. Conclusion - Wuweizi Ningshen Oral Liquid possesses obvious sedative, hypnotic and anti- convulsion effects.