摘要
目的：探讨川芎嗪（ＴＭＰ）对Ｂａ２＋诱发的心室肌细胞异常自律性的影响。方法：采用常规微电极技术。结果：ＴＭＰ５０～２００μｍｏｌ／Ｌ可剂量依从性使最大舒张电位（ＭＤＰ）减小和自动节律（ＳＲ）增快。利多卡因２μｍｏｌ／Ｌ可完全拮抗ＴＭＰ的上述作用。异搏定０６μｍｏｌ／Ｌ显著抑制ＳＲ，对ＭＤＰ无影响。结论：ＴＭＰ可阻滞心肌细胞外向Ｋ＋电流，其药物效应与异搏定不同。
Objective:To study the effect of Tetramethylpyrazine (TMP) on the abnormal automaticity elicied by Ba 2+ (4 mmol/L) in guinea pig papillary muscles.Methods:By means of standard microelectrode techniques.Results:TMP 50～200 μmol/L reduced maximum diastolic potential (MDP) and increased spontaneous rhythm (SR) in a dose-dependent manner.The TMP induced actions could be reversed by Lidocaine 2 μmol/L.Verapmil 0 6 μmol/L inhibited SR remarkably,but didn′t have effect on MDP.Conclusions:TMP had an inhibitory effect on the outwart K + current of the myocardium and differed greatly from verapamil in drug action.
出处
《中国冶金工业医学杂志》
1997年第3期131-133,共3页
Chinese Medical Journal of Metallurgical industry
关键词
川芎嗪
利多卡因
异搏定
异常自律性
药理
Tetramethylpyrazine
Lidocaine
Verapmil
Abnormal automaticity
