肺癌患者血清骨桥蛋白检测的临床价值

Value of serum osteopontin determination in patient with lung carcinoma

目的通过对不同组织学类型的肺癌患者血清骨桥蛋白(OPN)检测,探讨其在肺癌诊断中的临床价值。方法选择手术治疗的不同组织学类型的肺癌患者48例作为肺癌组,同期非肿瘤疾病患者45例作为疾病对照组,40例献血员作为健康对照组,用酶联免疫吸附试验法检测OPN,同时用化学发光免疫法检测细胞角蛋白-19(CYFRA21-1)、肿瘤相关抗原15-3(CA15-3)。结果肺癌患者组中的OPN、CYFRA21-1、CA15-3的阳性率分别是72.9%(35/48)、68.7%(33/48)、56.2%(27/48),特异性分别是91.1%(41/45)、68.8%(31/45)、57.7%(26/45)。OPN与CYFRA21-1、CA15-3联合检测的敏感度和特异性分别为83.2%、93.3%。结论血清OPN检测有助于肺癌的诊断,与CYFRA21-1、CA15-3联合检测可以明显提高对肺癌诊断的敏感性。

Objective To detect the levels of serum osteopontin in the patients with different histologic types of lung caicinoma. Methods Serum osteopontin （OPN）, cytokeratin-19 （CYFRA21-1）, carbohydrate antigen （CA15-3） were detected in 48 patients with lung carcinoma, 45 non-tumor patients and 40 donors by enzyme linked immunosorbent assy （ELISA） and chemiluminescence immunoasssy respectively. Results The positive rates of OPN, CYFRA21-1 and CA15-3 were 72.9%, 68.7% and 56.2% respectively. The specificity of OPN, CYFRA21- 1 and CA15-3 were 91. 1%, 68.8% and 57.7%. The sensitivity and specificity of combined tests of OPN, CFRA21- 1 and CA15-3 were 83.2%, 93.3%. Conclusion The serum OPN can be useful for the diagnosis of lung carcinoma. The combined use of OPN, CYFRA21-1, CA15-3 can elevate the diagnostic sensitivity.