间断或减量应用格列卫治疗胃肠间质瘤对疗效的影响分析

The Clinic Effect of Interrupting or Reducing the Use of Glivec on Gastrointestinal Stromal Tumor

目的:探讨格列卫治疗胃肠间质瘤的疗效与其剂量及疗程的关系。方法:在用格列卫400mg/d治疗GIST取得疗效后,减量或停用,观察疗效变化。结果:停药或减量后病情复发、加重,再次服药或加量服药后1例患者无效,另1例再次有效。结论:格列卫治疗胃肠间质瘤取得疗效后,应按有效剂量持续服用,停药或减量服用应慎重,以免引起疗效下降。

Objective：To explore the relationship between the dose,therapeutic course and clinic effect of Glivec used for treatment of gastrointestinal stromal tumer（GIST）.Methods：The change was observed by reducing the dose or stopping taking Glivec after getting effect at the dose of 400mg per day.Results：The patients＇ conditions were worsened or recured after reducing the dose of Glivec or stopping medication.After resumption of Glivec or increase of the dose the good result was shown in one case,but there was no improvement in another case.Conclution：Patients should keep on taking Glivec at effective dose after getting clinic effect.The medication should not be stopped,and the dose should not be decreased,so as not to cut down the effect.