蓝布正总提取物对高血糖动物降血糖作用的研究

The experimental study on the decreasing blood sugar of Aleppo Avens on mice of high blood sugar

目的:研究蓝布正对几种物质诱导高血糖动物血糖的影响。方法:用葡萄糖及肾上腺素致小鼠高血糖模型、四氧嘧啶致糖尿病小鼠模型,分别观察蓝布正对小鼠血糖、体重、饮水量和饮食量的影响。结果:蓝布正低、高剂量组都能降低葡萄糖性高血糖小鼠的血糖水平(P<0.05)。高剂量组能显著降低肾上腺素性高血糖小鼠的血糖水平(P<0.05);低剂量组对肾上腺素性高血糖模型无明显降低作用(P>0.05);低高剂量组均能显著降低四氧嘧啶致糖尿病小鼠的血糖水平(P<0.05,P<0.01),且呈一定的剂量依赖关系;还能减少动物的饮食及饮水量。结论:蓝布正对多种原因引起的高血糖均有一定的降糖作用。

Objective： To investigate the effect of decoction of Aleppo avens in decreasing blood sugar level in diabetes mellitus mice （DM）, Methods： DM mice models were induced by glucose, adrenalin and alloxan respectively, After treatment, the influence ofAleppo avens on blood sugar level in DM mice was observed. Results： The high-dose-group and low-dose-group of Aleppo Avens could both decrease the blood sugar of mice induced by glucose （P〈0.05）, the blood sugar level of mice that induced by the adrenalin significantly （P〈0.05） decreased in the high dose group, while in the low dose group the effect was not obvious （P〉0.05）. The blood sugar could obviously be decreased in both the high and low dosage groups induced by alloxan （P〈0.05） and symptoms such as polydipsia and polyphagia appeared. Conclusion： Aleppo Avens is effective in decreasing blood sugar level in DM mice.