甲型流感病毒感染BALB/c鼠动物模型的建立

The model of influenza virus A infection in BALB/c Mice

目的:建立甲型流感病毒感染BALB/c鼠动物模型,为研究病毒变异、致病机制及抗病毒药物筛选提供模型动物。方法:通过滴鼻的方法将甲型流感病毒感染到BALB/c鼠,观察小鼠的症状和组织病理改变。结果:BALB/c鼠的临床症状明显,病理变化典型。结论:甲型流感病毒感染BALB/c鼠的疾病模型建成。

Objective： To establish an influenza virus A infection model in BALB/c mice and to provide animal model for studying variation, pathogenic mechanism and anti-virus medicines screening. Method： The experimental mice were infected with influenza virus A. Then the clinical symptoms and the histopathological changes were observed. Result： The BALB/c mice had the clinical symptoms and typical lesion. Conclusion： The influenza virus A infected BALB/c mice model can be made.