藏药螃蟹甲的化学成分研究

Studies on the Chemical Constituents of Phlomis younghusbandii

目的:研究螃蟹甲地上部分的化学成分。方法:乙醇提取,氯仿、正丁醇依次萃取,硅胶柱层析分离纯化,通过理化常数和波谱分析鉴定化合物结构。结果:分离得到8个化合物,分别鉴定为8-乙酰山栀苷甲酯(8-ace-tylshanzhiside methyl ester)(1)、山栀苷甲酯(shanzhiside methyl ester)(2)、糙苏素(phlomiol)(3)、果糖丁苷(4)、sesamoside(5)、pulchelloside-Ⅰ(6)、木犀草素-7-O-β-D-葡萄糖苷(luteolin-7-O-β-D-glucopyranoside)(7)、胡萝卜苷(daucosterol)(8)。结论:上述化合物均为首次从螃蟹甲地上部分中分离得到。关键词螃蟹甲;

Objective： To study the ehemical constituents of Phlomis younghusbandii. Methods： Compounds were isolated from the ethanolic extract by silica gel column chromatography, and their structures were identified by physical and chemical evidences and spectral methods. Results ： Eight compounds were isolated and identified respectively as 8-acetylshanzhiside methyl ester （ 1 ） , shanzhiside methyl ester （ 2 ）, phlomiol （ 3 ）, 2-butoxy-2-（ hydroxymthyl ） tetrahydro-2H-3,4,5-pyrantriol （ 4 ）, sesamoside （ 5 ）, pulchelloside- Ⅰ （6） , luteolin-7-O-β-D-glucopyranoside （7） and daucosterol （8）. Conclusion ： All the compounds were isolated from the plant for the first lime.