摘要
目的:观察银丹心脑通软胶囊对代谢综合征(MS)及急性冠脉综合征(ACS)患者的血流变及血瘀证积分的影响,旨在探讨活血化瘀中药对MS及ACS患者高粘血症的临床作用。方法:63例MS合并ACS患者随机分成两组,治疗组服用银丹心脑通软胶囊(YD)和西药,对照组单纯服用西药,两组疗程为3个月;观察其血粘度变化及血瘀证积分改变。结果:两组治疗前后全血粘度、还原高切、纤维蛋白原及红细胞聚集指数和变形指数均有改善(P<0.05),且治疗组红细胞聚集指数较对照组明显好转(两组治疗后相比P<0.05)。治疗组患者胸痛症状减轻、发作次数或例数减少,舌质紫暗瘀斑、口唇齿龈暗等均有明显改善(P<0.01),血瘀证积分值明显下降(P<0.01),与对照组比较也有显著降低(P<0.01);对照组患者胸痛症状、血瘀证积分值也较治疗前显著下降(P<0.01),但其它血瘀症状未见显著改善。结论:银丹心脑通软胶囊不但可改善ACS患者的心绞痛症状和血瘀证积分,而且可改善MS患者的血流变,提示活血化瘀、行气止痛中药可能会通过改善患者的血液高粘滞状态而起到改善代谢及治疗心绞痛的作用。
Objeetive ： To observe the effect of Capsule YD on blood hemorheology and the score of blood stasis in patients with MS complicated ACS, and to investigate the clinical effect of Chinese medicine of promoting blood flow on those diseases. Methods ： 63 cases were divided into two groups. Control group was treated with routine methods and YD group with additional YD. The course of treatment was 3 months. Blood hemorheology and the score of blood stasis were observed. Results： Blood viseosity high shear rate,fibrinogen, the index and deformed index of Euthrocyte aggregation before and after treatment in hoth groups were improved （ P 〈 0. 05）. And the index of Erythroeyte aggregation in YD group was significantly improved comparing to that in control group（ P 〈0. 05 ）. The symtom of stethalgia, frequency of episode, and blood stasis on tongue, lip and gums were also improved in YD group. The value of blood stasis in YD group was significantly decreased comparing to that in control group. Conclusions： Capsule YD can improve the angina peetoris and decrease the value of blood stasis in patients with ACS, and also improve their hemorheology. We should presume the Chinese medicine of activating blood circulation to dissipate blood stasis improve the metabolism and treat angina peetoris by improving blood byperviscosity.
出处
《中药材》
CAS
CSCD
北大核心
2007年第10期1337-1340,共4页
Journal of Chinese Medicinal Materials
