细胞因子在急性心肌梗塞中的作用

The actions of cytokines in acute myocardial infarction

为探讨细胞因子在急性心肌梗塞（AMI）中的作用，测定了28例AMI患者血清肿瘤坏死因子α（TNFα）和白细胞介素1β（IL－β）水平，并选择13例不稳定型心绞痛（UA）患者和15例健康人作为对照。结果表明：AMI组血清TNFα水平明显高于UA组及正常组（P＜0．01），UA组血清TNFα水平明显高于正常组（P＜0．01）；血清IL－1β水平在严重的AMI患者（心功能KillipⅢ、Ⅳ级）明显高于正常组（P＜0．01）。提示血清TNFα和IL-1β水平与心肌缺血的严重程度有关。

To inquire into the actions of cytokines in acute myocardial infarction(AMI),we measured the levels of tumor necrosis factor α(TNF α)and interleukin1 β(IL-1β) of 28 patients with AMI. Meantime 13 unstable angina (UA) patients and 15 healthy people were selected as the controls. The results showed that the TNF α level of group AMI was higher markedly than that of UA and normal group (P <0.01 ),and the level of TNF α in group UA was more higher than normal group (P <0.01). The level of IL-1 βof serious patients with AMI (Killip class Ⅲ,Ⅳ )was higher more than normal group (P <0. 01). Our results suggested that the levels of TNF α and IL-1β connected with the serious degree of myocardial ischemia.