摘要
观察连续性高容量血液透析滤过对多器官功能障碍综合征(MODS)患者免疫功能和预后的影响。方法:对本院ICU住院的10例MODS患者行高容量连续性血液滤过72 h,观察治疗前后血常规、血生化和C-反应蛋白(CRP)的差异,并每24 h评价APACHE评分,测定血单核细胞HLA-DR表达。结果:所有患者均耐受高容量血液透析滤过,高容量血液透析滤过可以回调患者外周血白细胞计数(P<0.05),血CRP有下降(P<0.05),APACHE评分得到改善(P<0.01)。单核细胞HLA-DR表达随着时间的增加而相应上调。结论:高容量连续性血液滤过可以改善MODS患者免疫功能,促进免疫功能重建,改善预后。
Objective： To investigate the effects of continuous high volume hemofihration （CHVHF） on the immune function of MODS patients. Methods：A total of 10 patients diagnosed with MODS were selected in this study. All the patients received continuous high volume hemofihration [ the uhrafiltration （UF） flow rate at 6 L/hi for 72 hours, during which, the APACHE H scores and plasma monocyte HLA-DR were evaluated every 24 hours. Blood routine test,blood serum C reactive protein （CRP）and blood biochemistry were examined before and after CHVHF. Results： CHVHF was well tolerated in all the patients. The white blood cell count （ P 〈 0.05 ） and CRP （ P 〈 0. 05 ） decreased after the treatment. APACHE H scores were significantly improved at 48 hours of CHVHF（ P 〈 0.01 ）. The blood monocyte HLA-DR improved over time after the high volume hemofihration. Conclusion： high volume hemofihration can improve the immune function, which should favor the outcome of MODS patients.
出处
《广州医学院学报》
2007年第3期20-23,共4页
Academic Journal of Guangzhou Medical College
基金
广州市卫生局资助项目(2006-YB-151)
关键词
高容量血液透析滤过
MODS
预后
HLA-DR表达
high volume hemofiltration
MODS （ multiple organ dysfunction syndrome）
prognosis
HLA-DR express
