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非粘附性液体栓塞材料CoHEMA的研制现状 被引量：2

The application of a nonadhesive liquid embolic material-CoHEMA
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摘要 甲基丙烯酸-2-羟乙酯(2-hydroxyethyl methacrylate,HEMA)和甲基丙烯酸甲酯(methyl methacrylate,MMA)聚合物(CoHEMA)是一种新型的、非粘附性的液体栓塞材料,由以偶氮二异丁腈为引发剂,将甲基丙烯酸-2-羟乙酯(2-hydroxyethyl methacrylate,HEMA)和甲基丙烯酸甲酯(methylmethacrylate,MMA)聚合而成,由于其特有的性质,作为一种非黏附性的液体栓塞材料,该共聚物黏度低,容易通过输送微导管,生物相容性好,栓塞效果稳定,可用于脑动静脉畸形(AVM)的栓塞治疗。 CoHEMA is a new nonadhesive liquid embolic material composed of methylmethacrylate （MMA） and 2-hydroxyethyl- methacrylate （HEMA）, In view of its special physical characteristic with low viscosity, better biocompatibility, and embollc instability, and easy to be injected through delivery microcatheter, CoHEMA is an excellent non-adhesive embolic material and can be used in embol- ic treatment of cerebral AVM.
作者 张国栋 刘作勤
机构地区 山东大学医学院 山东省医学影像学研究所
出处 《医学影像学杂志》 2007年第11期1243-1245,共3页 Journal of Medical Imaging
关键词 甲基丙烯酸甲酯类 动静脉畸形 栓塞非粘附性 栓塞材料 Methylmethacrylates Arteriovenous malformations Nonadhesive Embolic material
分类号 R743.4 [医药卫生—神经病学与精神病学] R453.9 [医药卫生—治疗学]
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参考文献9

  • 1Jahan R,Murayama Y,Glbin YP,et al.Embolization of arteriovenous malformations with Onyx:clinicopathological experience in 23 patients [J].Neurosurgery,2001,48:984-985.
  • 2Murayama Y,Vinuela F,Ulhoa A,et al.Nonadhesive liquid embolic agent for cerebral arteriovenous malformations:preliminary histopathological studies in swine rete mirabile[J].Neurosurgery,1998,43:1164-1175.
  • 3Terada T,Nakamura Y,Nakai K,et al.Embolization of arteriovenous malformations with peripheral aneurysms using ethylene vinyl alcohol copolymer.Reprt of three cases[J].J Neurosurg,1991,75:655-660.
  • 4Hamada JI,Kai Y,Morioka M,et al.A mixture of etnylene vinyl alcohol copolymer and ethanol yielding a nonadhesive liquid emboic agent to treat cerebral arteriovenous malformationsinitial clinical experience [J].J Neurosurg,2002,97:881-888.
  • 5Kazekawa K,Iwata H,Shimozuru T,et al.Nontoxic embolic liquids for treatmentof arteriovenous malformations[J].J Biomed Mater Res,1997,38:79-86.
  • 6盛希忠,刘作勤,赵成如,孔令斌.甲基丙烯酸-2-羟基乙酯共聚物栓塞脑动静脉畸形的实验研究[J].中华医学杂志,2006,86(3):152-156. 被引量：5
  • 7SHENG Xi-zhong,LIU Zuo-qin,WU Le-bin,TANG Jun,ZHAO Cheng-ru,KONG Ling-bin,WANG Qin,WANG Chuan-dong.Technical feasibility and histopathologic studies of poly (N-isopropylacrylamide) as a non-adhesive embolic agent in swine rete mirabile[J].Chinese Medical Journal,2006(5):391-396. 被引量：3
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  • 9Pothmann D,Ulusans S,Prls F,et al.Liquid 2-P-HEMA for endovascular tumor therapy in vivo feasibility study[J].Med Sci Monit,2004,10:286-293.

二级参考文献10

  • 1Kazekawa K,Iwata H,Shimozuru T,et al.Nontoxic embolic liquids for treatment of arteriovenous malformations.J Biomed Mater Res,1997,38:79-86.
  • 2Terada T,Nakamura Y,Nakai K,et al.Embolization of arteriovenous malformations with peripheral aneurysms using ethylene vinyl alcohol copolymer.Report of three cases.J Neurosurg,1991,75:655-660.
  • 3Sadato A,Taki W,Ikada Y,et al.Experimental study and clinical use of poly(vinyl acetate) emulsion as liquid embolization material.Neuroradiology,1994,36:634-641.
  • 4Gobin YP,Vinuela F,Vinters HV,et al.Embolization with radiopaque microbeads of polyacrylonitrile hydrogel:evaluation in swine.Radiology,2000,214:113-119.
  • 5Wright KC,Greff R J,Price RE.Experimental evaluation of cellulose acetate NF and ethylene-vinyl alcohol copolymer for arterial embolization.J Vasc Interv Radiol,1999,10:1128-1207.
  • 6Yamashita K,Taki W,Iwata H,et al.Characteristics of ethylene vinyl alcohol copolymer (EVAL) mixtures.AJNR,1994,15:1103-1105.
  • 7Chaloupka JC,Huddle DC,Alderman J,et al.A reexamination of the angiotoxicity of superselective injection of DMSO in the swine rete embolization model.AJNR,1999,20:401-410.
  • 8Klisch J,Yin L,Requejo F,et al.Liquid 2-poly-hydroxyethyl-methacrylate embolization of experimental arteriovenous malformations:feasibility study.AJNR ,2002,23:422-429.
  • 9Pothmann D,Ulusans S,Pr(o)ls F,et al.Liquid 2-P-HEMA for endovascular tumor therapy in vivo feasibility study.Med Sci Monit,2004,10:BR286-293.
  • 10石忠松,黄正松,张跃卫,齐铁伟,初明,包大士.Experimental study of Eudragit mixture as a new nonadhesive liquid embolic material[J].Chinese Medical Journal,2002(4):555-558. 被引量：6

共引文献6

同被引文献40

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二级引证文献6

医学影像学杂志
2007年 第11期

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