摘要
目的:制备穿琥宁中空栓并建立其质量控制方法。方法:以半合成脂肪酸甘油酯为基质,以聚乙二醇300或1,2-丙二醇为分散媒,制备穿琥宁中空栓;采用紫外分光光度法测定主药穿琥宁的含量,测定波长为251nm。结果:穿琥宁检测浓度在6.0~50.0μg.mL-1范围内与吸光度呈良好线性关系(r=0.9999,n=5);2种穿琥宁中空栓的质量考查符合规定。结论:本方法合理、可行。
OBJECTIVE: To prepare Potassium dehydroandrographolide succinate (PDS) hollow suppository and establish a method for its quality control. METHODS: The PDS hollow suppository was prepared with semisynthesis fatty acid glyceride as ground substances and PEG300 or 1, 2 propylene glycol as disperse medium. The content of PDS was determined by ultra- violet spectrophotometry at a detection wavelength of 251nm. RESULTS: The linear concentration range of PDS was 6.0-50.0μg · mL^-1(r = 0. 999 9, n = 5) .The two kinds of PDS hollow suppository were all up to the quality standard. CONCLU- SION: This method is reasonable in design and feasible in technology.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第33期2586-2588,共3页
China Pharmacy
关键词
穿琥宁
中空栓
制备
紫外分光光度法
质量控制
Potassium dehydroandrographolide succinate(PDS)
Hollow suppository
Preparation
Ultraviolet spec-trophotometry
Quality control