摘要
目的:探讨含三七总皂苷类注射剂所致不良反应的一般规律及特点,推动临床合理用药。方法:检索1994~2006年国内公开发表的医学期刊报道应用三七总皂苷类注射剂致不良反应案例,对其进行统计分析。结果:81例含三七总皂苷类注射剂所致不良反应中,女性多于男性,并在高年龄组发生率较高,且多在再次或反复数次用药后发生。不良反应临床表现复杂多样,涉及机体多个器官系统损伤,主要是皮肤及其附件的损伤。结论:临床医师、药师应了解含三七总皂苷类注射剂所致不良反应的规律和特点,加强其应用的监测,以减少不良反应的发生。
OBJECTIVE: To study the general pattern and characteristics of the ADRs associated with Saponins of panax notoginseng (SPN) injection to guide rational administration of this drug. METHODS: ADR cases induced by SPN injection that retrieved from domestic medical journals between 1994 and 2006 were analyzed statistically. RESULTS: Of the total 81 ADR cases induced by SPN injection, females showing higher percentage than males, and the ADRs were more often seen in aged group. The ADRs usually occurred following second time injection or repeated injections, The clinical manifestations of ADRs varied and could involve multiple organs and systems, which were characterized predominantly by damages of skin and its appendages. CONCLUSION: Doctors and pharmacists should master the pattern and characteristics of ADRs and strengthen ADR monitoring so as to reduce the incidence of ADRs.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第33期2616-2618,共3页
China Pharmacy
关键词
三七总皂苷
注射剂
不良反应
文献
分析
Saponins of panax notoginseng
Injection
ADRs
Literature
Analysis