健中愈疡片对消炎痛大鼠胃粘膜前列腺素E_2含量的影响

Effect of Jianzhong Yuyang Tablets on Prostaglandin E_2 Content in Gastric Mucosa of Rats with Gastrointestinal Injury Induced by Indomethacin

【目的】观察健中愈疡片对非甾体抗炎药消炎痛所致胃肠道损伤大鼠胃粘膜前列腺素E2(PGE2)含量的影响。【方法】将SD大鼠随机分成7组:空白对照组,模型组,法莫替丁组(剂量为7.14 mg.kg-.1d-1),党参颗粒1、2组(剂量分别为0.71、2.84 g.kg-.1d-1),健中愈疡片1、2组(剂量分别为0.27、1.08 g.kg-.1d-1)。除空白对照组外,其他各组均皮下注射20 mg/kg消炎痛复制胃粘膜损伤模型;采用放射免疫法分别检测各组造模7 h和7 d后的胃粘膜组织PGE2的含量。【结果】造模7 h和7 d后各组胃粘膜组织PGE2的含量低于空白对照组(P<0.01),但各给药组均高于模型组(P<0.01)。造模7 d后各给药组分别与各自造模7 h后比较PGE2含量均有显著性提高(P<0.01)。【结论】健中愈疡片对胃肠道损伤的保护作用可能与其增加胃粘膜PGE2合成有关。

[ Objective ] To observe the effect of Jianzhong Yuyang Tablets （JYT） on content in gastric mucosa of rats with gastrointestinal injury induced by indomethacin. prostaglandin E2 （PGE2） [ Methods] One hundred and seven SD rats were randomized into 7 groups： blank control group, model group, famotidine （7.14 mg.kg^-1. d ^-1 ） group, two Radix Codonopsis （ RC, 0. 71 and 2. 84 g ·kg ^-1 . d ^- 1 respectively） groups, two JYT （0.27 and 1.08 g· kg^-1 · d^ -1 respectively） groups. Except the blank control group, the rats in other groups were given subcutaneous injection of indomethacin 20 mg/kg to induce gastrointestinal injury. PGE2 content in gastric mucosa of rats were detected with radioimmunoassay 7 hours and 7 days after modeling respectively. [ Results ] PGE2 content in gastric mucosa of model rats was lower than that in the blank control group 7 hours and 7 days after modeling （P 〈0.01 ）, and was higher in medication groups than that in the model group （P 〈 0.01 ）. PGE2 content in the medication groups 7 days after modeling was higher than that in the medication groups 7 hours after modeling （P 〈0. 01 ）. [ Conclusion] The protective mechanism of JYT on gastrointestinal tract injury is probably related with its enhancement of PEG2 synthesis in gastric mucosa.