羧甲基壳聚糖银噻苯咪唑水基复合抗菌剂的制备、表征及其抗菌性能(英文)

Preparation, Characterization and Antimicrobial Activity of Aqueous Complex Agents Ag-carboxymethyl Chitosan-thiabendazole

基于四种分子量壳聚糖(72.4,166,305和400kDa)制备了四种羧甲基壳聚糖银噻苯咪唑(Ag-CMCTS-TBZ)水基复合抗菌剂。用傅立叶红外光谱、动力光散射粒度检测和最小抑菌浓度测试对其理化生物性能进行了表征。结果表明,四种水基复合抗菌剂都具备良好的广谱抗菌性能,对大肠杆菌、金黄色葡萄球菌、白色念珠菌的最小抑菌浓度在30～125mg/L,对黑曲霉、毛霉的最小抑菌浓度在100～1800mg/L,但并非表观粒度越小抗菌性能越强。

Four aqueous complex agents of Ag-Carboxymethyl chitosan-thiabendazole （Ag-CMCTS-TBZ） were prepared using chitosans with molecular weights （MWs） of 72.4, 166,305 and 400 kDa respectively. FT-IR spectroscopy, ZetaPlus particle size analyzing and minimum inhibitory concentration （MIC） assessment were used to characterize them, and showed that the four agents have good antimicrobial activity with MICs ranging from 30 to 125 mg/L for bacteria Escherichia coli, Staphylococcus aureus and yeast Carutida albicaus and 100 - 1800 mg/L for fungi Aspergillus niger, Mucor sp. , and the smaller apparent diameter of the agents did not certainly lead to better antimicrobial activity within the range of 365 - 1229 nm.