中国围绝经期妇女体脂含量与骨密度关系的初步研究

Relationship between body composition and bone mineral density in healthy perimenopausal Chinese women

目的探讨肌肉、脂肪含量与围绝经期骨质疏松妇女骨密度之间的关系。方法利用双能X线骨密度测量仪（美国,Hologic DiscoveryA型）测量门诊围绝经期妇女（90例,年龄：45＊52岁（47.3±8.2））骨密度与体脂含量;同时测量登记受试者的年龄、身高、体重。结果结果显示,21%受试者腰椎和股骨骨量降低,全身脂肪含量（20675.129±5080.44）g与腰椎骨密度（0.91±0.177）g/cm^2（P〉0.05,r=-0.17）和髋部骨密度（0.99±0.102）g/cm2（P〉0.05,r=0.158）没有相关性,肌肉含量（39790.80±6551.54）g与腰椎骨密度没有相关性（P〉0.05,r=0.078）,但是与髋部骨密度高度正相关（P〈0.05,r=0.216）。体重（63.01±9.39）kg和腰椎（P〈0.05,r=0.217）和髋部（P〈0.05,r=0.305）骨密度高度正相关;BMI指数（24.6751±3.45637）与腰椎（P〈0.05,r=0.244）和髋部（P〈0.01,r=0.339）骨密度高度正相关。结论研究结果表明BMI指数和肌肉含量与围绝经期妇女髋部骨密度高度相关。

Objective To determine the independent effect and relative contribution of lean mass and fat mass to BMD in perimenopausal women. Methods The sample consisted of 90 sedentary perimenopausal women （age： 47.3± 8.2） .Total body BMD, regional BMD, and soft tissue body composition were measured by dual-energy X- ray ahsorptiometry（HOLOGIC（r） Discovery A）. Other measures including age, height, weight, and body mass index （BMI）. Results Findings revealed that 21% of these perimenopausal women had low bone mass （osteopenia） in the lumbar spine and/or the femoral neck. Overall body fat mass（20675.129 ±5080.44）g had no relationships with BMD of lumber spine（0.91 ± 0. 177） g/cm^2 （ P 〉 0.05, r = - 0.17） and the femur（0.99 ±0. 102） g/cm^2 （ P 〉 0.05, r = 0. 158）, and lean mass （39790.80 ±6551.54）g had no relationships with BMD of lumber spine （0.91 ± 0. 177） g/era2 （P 〉 0.05, r = 0.078）, but have positive relation with the BMD of femur（ P 〈 0.05, r = 0.216）. Weight （63.01 ± 9.39） kg and BMI had positive relationships with BMD of lumber spine and the femur（ P 〈 0.05 ）. Conclusions These findings suggest that BMI and body lean mass, not fat mass, are significant contributors to femoral BMD in women.