尿脱氧吡啶用于绝经前子宫切除妇女骨代谢变化检测的研究

An investigation of bone metabolism change with premenopausal hysterectomy women by DPD

目的探讨绝经前子宫切除妇女术后骨代谢改变的最早时期。方法采用酶联免疫吸附法(ELISA法)检测60例绝经前行子宫切除妇女术后不同时期的尿脱氧吡啶(DPD)和血清骨钙素(BGP)水平,同时用全自动生化分析仪检测血清碱性磷酸酶(ALP)水平。采用单因素方差分析进行统计学处理。结果与对照组的比较,手术后2年组,≥3年组ALP,BGP水平升高(分别为P<0.05;P<0.01);DPD显著升高(均P<0.01);与手术后1年组比较,手术后2年组BGP、DPD升高,差异有统计学意义(分别为P<0.05,P<0.01),ALP变化无统计学意义(P>0.05)。手术后≥3年组ALP、BGP、DPD升高,差异有统计学意义(均为P<0.01)。结论术后2年是骨代谢改变的敏感期,应进行检测与预防,DPD是一个敏感的反映骨吸收的生化指标。

Objective To find the earliest change time of bone metabolism for operation menopausal women. Methods Sixty women undergone hysterectomy with two annex conserved were recruited to this study. Urine DPD and serum BGP were detected with ELISA technique. Serum ALP were detected by automatism chemical instrument. Statistical analysis was performed with One-Way ANOVA. Results （1） Compare with the control group,the serum ALP,BGP levels are higher in two-year group（ P 〈 0.05）and significantly higher（ P 〈 0.01 ） in three-year than those in control group. Urine DPD level is higher in two-year group and three-year group than that in control group（ P 〈 0.01 ）. There is no change to every markers bwteen one-year group and contral group（ P 〉 0.05 ）. （2）Compare with one-year group, serum BGP level is higher in two-year group （ P 〈 0.05 ） and significantly higher（ P 〈 0.01） in three-year group than that in one-year group. Urine DPD level is higher（ P 〈 0.01 ）, too. Serum ALP is not higher in two-year group （ P 〉 0.05） than that in one-year group. But it is higher in three-year group（ P 〈 0.01 ）. Conclusions The 2th year after opertation is a danger period. We should routinely survey and prevent. The biochemical marker DPD is sensitive.