核结合因子a1的调控机制

The regulation of Cbfa1

Cbfa1是骨发育过程中调节骨髓基质干细胞向成骨细胞分化和成熟的重要转录因子。Cbfa1的表达水平异常与骨骼系统疾病有关。体内体外实验证实多种通路(如Wnt/LRP5/-catenin,BMP/Smads,1,25-(OH)2-vitaminD3/VDR/VDRE途径)和调节蛋白(Msx2,Dlx5,Twists)在Cbfa1基因表达、活性和随后的骨形成过程中起关键作用。这些发现对调控成骨细胞分化和治疗骨质疏松以及其他伴有骨量改变的疾病治疗提供了新的思路,这些疾病有可能用控制Cbfa1表达来进行治疗。

Cbfal is an accepted transcription factor essential for osteoblast development from mesenchymal stem cells and maturation into osteocytes and organize crucial events during bone formation. Alternations in Cbfal expression levels are associated with skeletal diseases. In vitro and in vivo studies have reported that muhiple integrated complex path ways （such as Wnt/LRPS/b-catenin, BMP/Smads, 1, 25-（OH）2-vitaminD3/VDR/VDRE pathway, etc. ） and several regulatory proteins （such as Msx2, DlxS, Twists, etc. ） play critical roles in modulating Cbfal gene expression, activity, and the subsequent bone formation. These findings provide novel insights through controlling osteoblast differentiation to treat osteoporosis or other bone diseases with altered bone mass by stimulating Cbfalexpression.